Corosolic Acid Attenuates the Invasiveness of Glioblastoma Cells by Promoting CHIP-Mediated AXL Degradation and Inhibiting GAS6/AXL/JAK Axis

Corosolic Acid Attenuates the Invasiveness of Glioblastoma Cells by Promoting CHIP-Mediated AXL Degradation and Inhibiting GAS6/AXL/JAK Axis

Corosolic acid (CA), a bioactive compound obtained from Actinidia chinensis, has potential anti-cancer activities. Glioblastoma (GBM) is a malignant brain tumor and whether CA exerts anti-cancer activity on GBM remains unclear. This study was aimed to explore the anticancer activity and its underlyi...

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Bibliographic Details
Main Authors: Li-Wei Sun, Shao-Hsuan Kao, Shun-Fa Yang, Shang-Wun Jhang, Yi-Chen Lin, Chien-Min Chen, Yi-Hsien Hsieh
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cells
Subjects:
corosolic acid
glioblastoma cell
invasiveness
AXL
CHIP
GAS6
Online Access:https://www.mdpi.com/2073-4409/10/11/2919

Internet

https://www.mdpi.com/2073-4409/10/11/2919

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