Fine-tuning the antigen sensitivity of CAR T cells: emerging strategies and current challenges

Fine-tuning the antigen sensitivity of CAR T cells: emerging strategies and current challenges

Chimeric antigen receptor (CAR) T cells are “living drugs” that specifically recognize their target antigen through an antibody-derived binding domain resulting in T cell activation, expansion, and destruction of cognate target cells. The FDA/EMA approval of CAR T cells for the treatment of B cell m...

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Bibliographic Details
Main Authors: Dennis Christoph Harrer, Sin-Syue Li, Marcell Kaljanac, Markus Barden, Hong Pan, Hinrich Abken
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Immunology
Subjects:
CAR
antigen downregulation
antigen escape
antigen sensitivity
targeting selectivity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1321596/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1321596/full

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