Evaluation of KRAS, NRAS and BRAF mutations detection in plasma using an automated system for patients with metastatic colorectal cancer.

Evaluation of KRAS, NRAS and BRAF mutations detection in plasma using an automated system for patients with metastatic colorectal cancer.

<h4>Background</h4>Cell-free DNA detection is becoming a surrogate assay for tumor genotyping. Biological fluids often content a very low amount of cell-free tumor DNA and assays able to detect very low allele frequency mutant with a few quantities of DNA are required. We evaluated the a...

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Bibliographic Details
Main Authors: Claire Franczak, Andréa Witz, Karen Geoffroy, Jessica Demange, Marie Rouyer, Marie Husson, Vincent Massard, Céline Gavoille, Aurélien Lambert, Pauline Gilson, Nicolas Gambier, Julien Scala-Bertola, Jean-Louis Merlin, Alexandre Harlé
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0227294&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0227294&type=printable

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