The curious case of Merkel cell carcinoma: epigenetic youth and lack of pluripotency

The curious case of Merkel cell carcinoma: epigenetic youth and lack of pluripotency

Merkel cell carcinoma (MCC) is a very rare, but highly aggressive skin cancer which occurs mainly in elderly patients. MCC cells show an expression pattern of three cell lineages: epithelial, neuroendocrine, and B-cell progenitor. This trilinear expression pattern suggests stemness activity in MCC....

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Bibliographic Details
Main Authors: Emil Chteinberg, Julia Vogt, Julia Kolarova, Felix Bormann, Joost van den Oord, Ernst Jan Speel, Véronique Winnepenninckx, Anna Kordelia Kurz, Martin Zenke, Reiner Siebert, Axel zur Hausen
Format: Article
Language:English
Published: Taylor & Francis Group 2020-12-01
Series:Epigenetics
Subjects:
horvath’s epigenetic clock
merkel cell carcinoma
merkel cell polyomavirus
pluritest
dna methylation age
Online Access:http://dx.doi.org/10.1080/15592294.2020.1773096

Internet

http://dx.doi.org/10.1080/15592294.2020.1773096

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