Soluble amyloid-beta isoforms predict downstream Alzheimer’s disease pathology

Soluble amyloid-beta isoforms predict downstream Alzheimer’s disease pathology

Abstract Background Changes in soluble amyloid-beta (Aβ) levels in cerebrospinal fluid (CSF) are detectable at early preclinical stages of Alzheimer’s disease (AD). However, whether Aβ levels can predict downstream AD pathological features in cognitively unimpaired (CU) individuals remains unclear....

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Bibliographic Details
Main Authors: Guilherme Povala, Bruna Bellaver, Marco Antônio De Bastiani, Wagner S. Brum, Pamela C. L. Ferreira, Andrei Bieger, Tharick A. Pascoal, Andrea L. Benedet, Diogo O. Souza, Ricardo M. Araujo, Bruno Zatt, Pedro Rosa-Neto, Eduardo R. Zimmer, for the Alzheimer’s Disease Neuroimaging Initiative
Format: Article
Language:English
Published: BMC 2021-12-01
Series:Cell & Bioscience
Subjects:
Alzheimer’s disease
Amyloid-beta
Tau pathology
Neurodegeneration
Machine learning
Proteomics
Online Access:https://doi.org/10.1186/s13578-021-00712-3

Internet

https://doi.org/10.1186/s13578-021-00712-3

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