Placenta mesenchymal stem cell-derived extracellular vesicles alleviate liver fibrosis by inactivating hepatic stellate cells through a miR-378c/SKP2 axis

Placenta mesenchymal stem cell-derived extracellular vesicles alleviate liver fibrosis by inactivating hepatic stellate cells through a miR-378c/SKP2 axis

Abstract Background Extracellular vesicles derived from mesenchymal stem/stromal cells (MSCs) have shown therapeutic effects on liver fibrosis. This study aimed to evaluate the effects of extracellular vesicles from placenta-derived MSCs (Pd-MSCs-EVs) on liver fibrosis at 3D/2D levels and explore th...

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Bibliographic Details
Main Authors: Wenjie Zheng, Saiyan Bian, Shi Qiu, Colin E. Bishop, Meimei Wan, Nuo Xu, Xieyin Sun, Russel Clive Sequeira, Anthony Atala, Zhifeng Gu, Weixin Zhao
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Inflammation and Regeneration
Subjects:
Mesenchymal stem/stromal cells
Extracellular vesicles
Multicellular organoids
Liver fibrosis
miR-378c
Online Access:https://doi.org/10.1186/s41232-023-00297-z

Internet

https://doi.org/10.1186/s41232-023-00297-z

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