Loss of PTEN in Fallopian Tube Epithelium Results in Multicellular Tumor Spheroid Formation and Metastasis to the Ovary

Loss of PTEN in Fallopian Tube Epithelium Results in Multicellular Tumor Spheroid Formation and Metastasis to the Ovary

High-grade serous ovarian cancer (HGSOC) can originate in the fallopian tube and then spread to the ovary. Our objective was to evaluate the role of multicellular tumor spheroids (MTS) in ovarian metastasis. By testing a panel of murine oviductal epithelial (MOE) cells with genetic alterations mimic...

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Bibliographic Details
Main Authors: Matthew Dean, Vivian Jin, Tova M. Bergsten, Julia R. Austin, Daniel D. Lantvit, Angela Russo, Joanna E. Burdette
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cancers
Subjects:
ovary
cancer
PTEN
metastasis
oviduct
fallopian tube
spheroid
Online Access:https://www.mdpi.com/2072-6694/11/6/884

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https://www.mdpi.com/2072-6694/11/6/884

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