Enteric α-synuclein impairs intestinal epithelial barrier through caspase-1-inflammasome signaling in Parkinson’s disease before brain pathology

Enteric α-synuclein impairs intestinal epithelial barrier through caspase-1-inflammasome signaling in Parkinson’s disease before brain pathology

Abstracts Bowel inflammation, impaired intestinal epithelial barrier (IEB), and gut dysbiosis could represent early events in Parkinson’s disease (PD). This study examined, in a descriptive manner, the correlation among enteric α-synuclein, bowel inflammation, impairments of IEB and alterations of e...

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Bibliographic Details
Main Authors: C. Pellegrini, V. D’Antongiovanni, F. Miraglia, L. Rota, L. Benvenuti, C. Di Salvo, G. Testa, S. Capsoni, G. Carta, L. Antonioli, A. Cattaneo, C. Blandizzi, E. Colla, M. Fornai
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-021-00263-x

Internet

https://doi.org/10.1038/s41531-021-00263-x

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