Disruption of the Putative Vascular Leak Peptide Sequence in the Stabilized Ricin Vaccine Candidate RTA1-33/44-198

Disruption of the Putative Vascular Leak Peptide Sequence in the Stabilized Ricin Vaccine Candidate RTA1-33/44-198

Vitetta and colleagues identified and characterized a putative vascular leak peptide (VLP) consensus sequence in recombinant ricin toxin A-chain (RTA) that contributed to dose-limiting human toxicity when RTA was administered intravenously in large quantities during chemotherapy. We disrupted this p...

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Bibliographic Details
Main Authors: Charles B. Millard, Gary R. Matyas, Jon M. Davis, Keith E. Steele, Patricia M. Legler, Jaimee R. Compton, Laszlo Janosi
Format: Article
Language:English
Published: MDPI AG 2013-01-01
Series:Toxins
Subjects:
ricin
recombinant vaccines
vascular leak peptide
amino acid substitutions
BALB/c mice
D75N/R48C/T77C
RTA1-33/44-198
Online Access:http://www.mdpi.com/2072-6651/5/2/224

Internet

http://www.mdpi.com/2072-6651/5/2/224

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