Disruption of the Putative Vascular Leak Peptide Sequence in the Stabilized Ricin Vaccine Candidate RTA1-33/44-198
Vitetta and colleagues identified and characterized a putative vascular leak peptide (VLP) consensus sequence in recombinant ricin toxin A-chain (RTA) that contributed to dose-limiting human toxicity when RTA was administered intravenously in large quantities during chemotherapy. We disrupted this p...
Main Authors: | Charles B. Millard, Gary R. Matyas, Jon M. Davis, Keith E. Steele, Patricia M. Legler, Jaimee R. Compton, Laszlo Janosi |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2013-01-01
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Series: | Toxins |
Subjects: | |
Online Access: | http://www.mdpi.com/2072-6651/5/2/224 |
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