A Physiologically Based Pharmacokinetic (PBPK) Modeling Framework for Mixtures of Dioxin-like Compounds

Humans are exposed to persistent organic pollutants, such as dioxin-like compounds (DLCs), as mixtures. Understanding and predicting the toxicokinetics and thus internal burden of major constituents of a DLC mixture is important for assessing their contributions to health risks. PBPK models, includi...

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Bibliographic Details
Main Authors: Rongrui Liu, Tim R. Zacharewski, Rory B. Conolly, Qiang Zhang
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Toxics
Subjects:
Online Access:https://www.mdpi.com/2305-6304/10/11/700