Electrochemical studies of ciprofloxacin and its interaction with DNA(环丙沙星与DNA相互作用的电化学研究)

研究了环丙沙星(CFX)在自制的浸蜡石墨电极上的电化学特性,示差脉冲伏安法发现CFX在0.88 V处有一明显的氧化峰,DNA的加入使这一氧化峰明显减弱.采用所推导的电化学公式对实验数据进行了非线性拟合,同时获得了CFX与DNA的结合常数(K=1.36105(mol/L)-1)和结合位点数(s= 1.94),并探讨了CFX与小牛胸腺DNA的结合机理....

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Bibliographic Details
Main Authors: SHIQiao-cui(时巧翠), WANGSu-fen(王素芬), ZHUBin(朱斌), JIMin(季敏)
Format: Article
Language:zho
Published: Zhejiang University Press 2007-05-01
Series:Zhejiang Daxue xuebao. Lixue ban
Subjects:
Online Access:https://doi.org/zjup/1008-9497.2007.34.3.330-334