Exophilin-8 assembles secretory granules for exocytosis in the actin cortex via interaction with RIM-BP2 and myosin-VIIa

Exophilin-8 assembles secretory granules for exocytosis in the actin cortex via interaction with RIM-BP2 and myosin-VIIa

Exophilin-8 has been reported to play a role in anchoring secretory granules within the actin cortex, due to its direct binding activities to Rab27 on the granule membrane and to F-actin and its motor protein, myosin-Va. Here, we show that exophilin-8 accumulates granules in the cortical F-actin net...

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Bibliographic Details
Main Authors: Fushun Fan, Kohichi Matsunaga, Hao Wang, Ray Ishizaki, Eri Kobayashi, Hiroshi Kiyonari, Yoshiko Mukumoto, Katsuhide Okunishi, Tetsuro Izumi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-07-01
Series:eLife
Subjects:
diabetes
insulin
pancreatic β cell
Rab27
secretion
Online Access:https://elifesciences.org/articles/26174

Internet

https://elifesciences.org/articles/26174

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