Microvasculopathy-Related Hemorrhagic Tissue Deposition of Iron May Contribute to Fibrosis in Systemic Sclerosis: Hypothesis-Generating Insights from the Literature and Preliminary Findings

Microvasculopathy-Related Hemorrhagic Tissue Deposition of Iron May Contribute to Fibrosis in Systemic Sclerosis: Hypothesis-Generating Insights from the Literature and Preliminary Findings

Microvascular wall abnormalities demonstrated by nailfold capillaroscopy in systemic sclerosis (SSc) may result in microhemorrhagic deposition of erythrocyte-derived iron. Such abnormalities precede fibrosis, which is orchestrated by myofibroblasts. Iron induces endothelial-to-mesenchymal transition...

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Bibliographic Details
Main Authors: Petros P. Sfikakis, Nikolaos I. Vlachogiannis, Panagiotis A. Ntouros, Sophie Mavrogeni, Thomas G. Maris, Apostolos H. Karantanas, Vassilis L. Souliotis
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Life
Subjects:
systemic sclerosis
fibrosis
iron deposition
oxidative stress
vasculopathy
MR imaging/quantification
Online Access:https://www.mdpi.com/2075-1729/12/3/430

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https://www.mdpi.com/2075-1729/12/3/430

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