High levels of SOX5 decrease proliferative capacity of human B cells, but permit plasmablast differentiation.

High levels of SOX5 decrease proliferative capacity of human B cells, but permit plasmablast differentiation.

Currently very little is known about the differential expression and function of the transcription factor SOX5 during B cell maturation. We identified two new splice variants of SOX5 in human B cells, encoding the known L-SOX5B isoform and a new shorter isoform L-SOX5F. The SOX5 transcripts are high...

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Bibliographic Details
Main Authors: Mirzokhid Rakhmanov, Heiko Sic, Anne-Kathrin Kienzler, Beate Fischer, Marta Rizzi, Maximilian Seidl, Kerstina Melkaoui, Susanne Unger, Luisa Moehle, Nadine E Schmit, Sachin D Deshmukh, Cemil Korcan Ayata, Wolfgang Schuh, Zhibing Zhang, François-Loic Cosset, Els Verhoeyen, Hans-Hartmut Peter, Reinhard E Voll, Ulrich Salzer, Hermann Eibel, Klaus Warnatz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4063782?pdf=render

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http://europepmc.org/articles/PMC4063782?pdf=render

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