Label-Free Sensing of Adenosine Based on Force Variations Induced by Molecular Recognition

Label-Free Sensing of Adenosine Based on Force Variations Induced by Molecular Recognition

We demonstrate a simple force-based label-free strategy for the highly sensitive sensing of adenosine. An adenosine ssDNA aptamer was bound onto an atomic force microscopy (AFM) probe by covalent modification, and the molecular-interface adsorption force between the aptamer and a flat graphite surfa...

Full description

Bibliographic Details
Main Authors: Jingfeng Li, Qing Li, Lucio Colombi Ciacchi, Gang Wei
Format: Article
Language:English
Published: MDPI AG 2015-03-01
Series:Biosensors
Subjects:
label-free sensing
adenosine
AFM
single-molecule force spectroscopy
aptamer
molecular recognition
Online Access:http://www.mdpi.com/2079-6374/5/1/85

Internet

http://www.mdpi.com/2079-6374/5/1/85

Similar Items