4-Heteroaryl Substituted Amino-3,5-Dicyanopyridines as New Adenosine Receptor Ligands: Novel Insights on Structure-Activity Relationships and Perspectives

4-Heteroaryl Substituted Amino-3,5-Dicyanopyridines as New Adenosine Receptor Ligands: Novel Insights on Structure-Activity Relationships and Perspectives

A new set of amino-3,5-dicyanopyridines was synthesized and biologically evaluated at the adenosine receptors (ARs). This chemical class is particularly versatile, as small structural modifications can influence not only affinity and selectivity, but also the pharmacological profile. Thus, in order...

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Bibliographic Details
Main Authors: Daniela Catarzi, Flavia Varano, Erica Vigiani, Sara Calenda, Fabrizio Melani, Katia Varani, Fabrizio Vincenzi, Silvia Pasquini, Natascia Mennini, Giulia Nerli, Diego Dal Ben, Rosaria Volpini, Vittoria Colotta
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Pharmaceuticals
Subjects:
G-protein-coupled receptors
adenosine receptor ligands
aminopyridine-3,5-dicarbonitriles
ligand-adenosine receptor modeling studies
Online Access:https://www.mdpi.com/1424-8247/15/4/478

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https://www.mdpi.com/1424-8247/15/4/478

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