Exploring Zebrafish Larvae as a COVID-19 Model: Probable Abortive SARS-CoV-2 Replication in the Swim Bladder

Exploring Zebrafish Larvae as a COVID-19 Model: Probable Abortive SARS-CoV-2 Replication in the Swim Bladder

Animal models are essential to understanding COVID-19 pathophysiology and for preclinical assessment of drugs and other therapeutic or prophylactic interventions. We explored the small, cheap, and transparent zebrafish larva as a potential host for SARS-CoV-2. Bath exposure, as well as microinjectio...

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Bibliographic Details
Main Authors: Valerio Laghi, Veronica Rezelj, Laurent Boucontet, Maxence Frétaud, Bruno Da Costa, Pierre Boudinot, Irene Salinas, Georges Lutfalla, Marco Vignuzzi, Jean-Pierre Levraud
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
SARS-CoV-2
zebrafish
animal model
swim bladder
type I interferon
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.790851/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2022.790851/full

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