Identification of MET fusions as novel therapeutic targets sensitive to MET inhibitors in lung cancer

Identification of MET fusions as novel therapeutic targets sensitive to MET inhibitors in lung cancer

Abstract Introduction Alterations in the MET gene, including amplifications and exon 14 skipping mutations, have been identified as actionable oncogenic alterations. However, MET fusions are rarely detected in lung cancer, and their sensitivity to therapeutics has not been systematically analyzed. M...

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Bibliographic Details
Main Authors: Dantong Sun, Weizheng Wu, Li Wang, Jialin Qu, Qiman Han, Huiyun Wang, Shanai Song, Ning Liu, Yongjie Wang, Helei Hou
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Journal of Translational Medicine
Subjects:
Lung cancer
Driver mutations
MET fusions
Tyrosine kinase inhibitors
LAVA database
Online Access:https://doi.org/10.1186/s12967-023-03999-7

Internet

https://doi.org/10.1186/s12967-023-03999-7

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