CHEX-seq detects single-cell genomic single-stranded DNA with catalytical potential

CHEX-seq detects single-cell genomic single-stranded DNA with catalytical potential

Abstract Genomic DNA (gDNA) undergoes structural interconversion between single- and double-stranded states during transcription, DNA repair and replication, which is critical for cellular homeostasis. We describe “CHEX-seq” which identifies the single-stranded DNA (ssDNA) in situ in individual cell...

Full description

Bibliographic Details
Main Authors: Youtao Lu, Jaehee Lee, Jifen Li, Srinivasa Rao Allu, Jinhui Wang, HyunBum Kim, Kevin L. Bullaughey, Stephen A. Fisher, C. Erik Nordgren, Jean G. Rosario, Stewart A. Anderson, Alexandra V. Ulyanova, Steven Brem, H. Isaac Chen, John A. Wolf, M. Sean Grady, Sergei A. Vinogradov, Junhyong Kim, James Eberwine
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-43158-6

Internet

https://doi.org/10.1038/s41467-023-43158-6

Similar Items