FLCN Regulates HIF2α Nuclear Import and Proliferation of Clear Cell Renal Cell Carcinoma

FLCN Regulates HIF2α Nuclear Import and Proliferation of Clear Cell Renal Cell Carcinoma

Aims and Hypothesis: This study aims to explore the specific molecular mechanism of folliculin (FLCN)-induced proliferation, migration, and invasion in clear cell renal cell carcinoma (ccRCC) and to investigate the relationship of FLCN and HIF2α. Folliculin was identified as a tumor suppressor gene....

Full description

Bibliographic Details
Main Authors: Xuyang Zhao, Yadong Ma, Jie Cui, Haiyang Zhao, Lei Liu, Yueyuan Wang, Pengxiang Min, Lin Zhang, Yongchang Chen, Jun Du, Yujie Zhang, Luo Gu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Molecular Biosciences
Subjects:
FLCN
mTORC2
HIF2α
nuclear import
cell proliferation
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.00121/full

Internet

https://www.frontiersin.org/article/10.3389/fmolb.2020.00121/full

Similar Items