Retrogradely Transported TrkA Endosomes Signal Locally within Dendrites to Maintain Sympathetic Neuron Synapses

Retrogradely Transported TrkA Endosomes Signal Locally within Dendrites to Maintain Sympathetic Neuron Synapses

Sympathetic neurons require NGF from their target fields for survival, axonal target innervation, dendritic growth and formation, and maintenance of synaptic inputs from preganglionic neurons. Target-derived NGF signals are propagated retrogradely, from distal axons to somata of sympathetic neurons...

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Bibliographic Details
Main Authors: Kathryn M. Lehigh, Katherine M. West, David D. Ginty
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Cell Reports
Subjects:
TrkA
signaling endosome
neurotrophin
sympathetic neuron
dendrites
synapse formation
ptosis
NFG
PLGA microspheres
microfluidic chambers
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717303601

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http://www.sciencedirect.com/science/article/pii/S2211124717303601

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