Matrix Metalloproteinases Contribute to the Calcification Phenotype in Pseudoxanthoma Elasticum

Matrix Metalloproteinases Contribute to the Calcification Phenotype in Pseudoxanthoma Elasticum

Ectopic calcification and dysregulated extracellular matrix remodeling are prominent hallmarks of the complex heterogenous pathobiochemistry of pseudoxanthoma elasticum (PXE). The disease arises from mutations in <i>ABCC6</i>, an ATP-binding cassette transporter expressed predominantly i...

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Bibliographic Details
Main Authors: Ricarda Plümers, Christopher Lindenkamp, Michel Robin Osterhage, Cornelius Knabbe, Doris Hendig
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Biomolecules
Subjects:
Abcc6
calcification
matrix metalloproteinase
Marimastat
pseudoxanthoma elasticum
Online Access:https://www.mdpi.com/2218-273X/13/4/672

Internet

https://www.mdpi.com/2218-273X/13/4/672

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