6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro

6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro

Summary: The emergence of SARS-CoV-2 has led to a global health crisis that, in addition to vaccines and immunomodulatory therapies, calls for the identification of antiviral therapeutics. The papain-like protease (PLpro) activity of nsp3 is an attractive drug target as it is essential for viral pol...

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Bibliographic Details
Main Authors: Caleb D. Swaim, Varun Dwivedi, Yi-Chieh Perng, Xu Zhao, Larissa A. Canadeo, Houda H. Harastani, Tamarand L. Darling, Adrianus C.M. Boon, Deborah J. Lenschow, Viraj Kulkarni, Jon M. Huibregtse
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:iScience
Subjects:
Therapeutics
Drugs
Virology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221011810

Internet

http://www.sciencedirect.com/science/article/pii/S2589004221011810

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