Mouse fetal growth restriction through parental and fetal immune gene variation and intercellular communications cascade

Mouse fetal growth restriction through parental and fetal immune gene variation and intercellular communications cascade

Natural Killer cells regulate foetal growth. Here the authors use a humanized transgenic mouse to demonstrate that specific HLA-C KIR2DL interactions promote changes in maternal and foetal cell transcriptomes, resulting in modifications to placental vasculature, intercellular communications and foet...

Full description

Bibliographic Details
Main Authors: Gurman Kaur, Caroline B. M. Porter, Orr Ashenberg, Jack Lee, Samantha J. Riesenfeld, Matan Hofree, Maria Aggelakopoulou, Ayshwarya Subramanian, Subita Balaram Kuttikkatte, Kathrine E. Attfield, Christiane A. E. Desel, Jessica L. Davies, Hayley G. Evans, Inbal Avraham-Davidi, Lan T. Nguyen, Danielle A. Dionne, Anna E. Neumann, Lise Torp Jensen, Thomas R. Barber, Elizabeth Soilleux, Mary Carrington, Gil McVean, Orit Rozenblatt-Rosen, Aviv Regev, Lars Fugger
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-32171-w

Internet

https://doi.org/10.1038/s41467-022-32171-w

Similar Items