PIK3R1 fusion drives chemoresistance in ovarian cancer by activating ERK1/2 and inducing rod and ring-like structures

PIK3R1 fusion drives chemoresistance in ovarian cancer by activating ERK1/2 and inducing rod and ring-like structures

Gene fusions are common in high-grade serous ovarian cancer (HGSC). Such genetic lesions may promote tumorigenesis, but the pathogenic mechanisms are currently poorly understood. Here, we investigated the role of a PIK3R1-CCDC178 fusion identified from a patient with advanced HGSC. We show that the...

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Bibliographic Details
Main Authors: Heidi Rausio, Alejandra Cervera, Vanina D. Heuser, Gun West, Jaana Oikkonen, Elena Pianfetti, Marta Lovino, Elisa Ficarra, Pekka Taimen, Johanna Hynninen, Rainer Lehtonen, Sampsa Hautaniemi, Olli Carpén, Kaisa Huhtinen
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
High-grade serous ovarian cancer
Fusion gene
Rods and rings (RRs)
Platinum resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558624000241

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http://www.sciencedirect.com/science/article/pii/S1476558624000241

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