Human Lung Mast Cells Impair Corticosteroid Responsiveness in Human Airway Smooth Muscle Cells

Human Lung Mast Cells Impair Corticosteroid Responsiveness in Human Airway Smooth Muscle Cells

The mechanisms underlying corticosteroid insensitivity in severe asthma have not been elucidated although some indirect clinical evidence points toward a role of mast cells. Here, we tested the hypothesis that mast cells can drive corticosteroid insensitivity in airway smooth muscle cells, a key pla...

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Bibliographic Details
Main Authors: Abdulrahman Alzahrani, Jameel Hakeem, Michael Biddle, Fahad Alhadian, Aamir Hussain, Latifa Khalfaoui, Katy M. Roach, Omar Tliba, Peter Bradding, Yassine Amrani
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Allergy
Subjects:
severe asthma
corticosteroid resistance
mast cell (MC)
growth factors
gene array
Online Access:https://www.frontiersin.org/articles/10.3389/falgy.2021.785100/full

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https://www.frontiersin.org/articles/10.3389/falgy.2021.785100/full

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