Structural modeling of the hERG potassium channel and associated drug interactions

Structural modeling of the hERG potassium channel and associated drug interactions

The voltage-gated potassium channel, KV11.1, encoded by the human Ether-à-go-go-Related Gene (hERG), is expressed in cardiac myocytes, where it is crucial for the membrane repolarization of the action potential. Gating of the hERG channel is characterized by rapid, voltage-dependent, C-type inactiva...

Full description

Bibliographic Details
Main Authors: Jan Maly, Aiyana M. Emigh, Kevin R. DeMarco, Kazuharu Furutani, Jon T. Sack, Colleen E. Clancy, Igor Vorobyov, Vladimir Yarov-Yarovoy
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
hERG channel
potassium channel
inactivation
drug block
Rosetta
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.966463/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.966463/full

Similar Items