Two Faces of Water in the Formation and Stabilization of Multicomponent Crystals of Zwitterionic Drug-Like Compounds

Two Faces of Water in the Formation and Stabilization of Multicomponent Crystals of Zwitterionic Drug-Like Compounds

Two new hydrated multicomponent crystals of zwitterionic 2-aminonicotinic acid with maleic and fumaric acids have been obtained and thoroughly characterized by a variety of experimental (X-ray analysis and terahertz Raman spectroscopy) and theoretical periodic density functional theory calculations,...

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Bibliographic Details
Main Authors: Artem O. Surov, Nikita A. Vasilev, Andrei V. Churakov, Olga D. Parashchuk, Sergei V. Artobolevskii, Oleg A. Alatortsev, Denis E. Makhrov, Mikhail V. Vener
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Symmetry
Subjects:
2-aminonicotinic acid
maleic and fumaric acids
intra- and inter-molecular hydrogen bonds
structure-directing role of water
periodic (solid-state) DFT computations
low-frequency Raman spectrum
Online Access:https://www.mdpi.com/2073-8994/13/3/425

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https://www.mdpi.com/2073-8994/13/3/425

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