B-cell intrinsic regulation of antibody mediated immunity by histone H2A deubiquitinase BAP1

B-cell intrinsic regulation of antibody mediated immunity by histone H2A deubiquitinase BAP1

IntroductionBAP1 is a deubiquitinase (DUB) of the Ubiquitin C-terminal Hydrolase (UCH) family that regulates gene expression and other cellular processes, through its direct catalytic activity on the repressive epigenetic mark histone H2AK119ub, as well as on several other substrates. BAP1 is also a...

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Bibliographic Details
Main Authors: Yue Liang, HanChen Wang, Noé Seija, Yun Hsiao Lin, Lin Tze Tung, Javier M. Di Noia, David Langlais, Anastasia Nijnik
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
B cell
humoral immune response
epigenetic regulation and gene expression
mouse model
germinal center (GC) B cells
class switch recombination
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1353138/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1353138/full

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