Development of high-growth influenza H7N9 prepandemic candidate vaccine viruses in suspension MDCK cells

Development of high-growth influenza H7N9 prepandemic candidate vaccine viruses in suspension MDCK cells

Abstract Background Influenza vaccine manufacturers traditionally use egg-derived candidate vaccine viruses (CVVs) to produce high-yield influenza viruses for seasonal or pandemic vaccines; however, these egg-derived CVVs need an adaptation process for the virus to grow in mammalian cells. The low y...

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Bibliographic Details
Main Authors: Tsai-Teng Tzeng, Po-Ling Chen, Tsai-Chuan Weng, Shin-Yi Tsai, Chia-Chun Lai, Hsin-I Chou, Pin-Wen Chen, Chia-Chun Lu, Ming-Tsan Liu, Wang-Chou Sung, Min-Shi Lee, Alan Yung-Chih Hu
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Journal of Biomedical Science
Subjects:
H7N9
Highly pathogenic avian influenza
Candidate vaccine virus
Suspension MDCK cells
Chemically defined medium
Reverse genetics
Online Access:http://link.springer.com/article/10.1186/s12929-020-00645-y

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http://link.springer.com/article/10.1186/s12929-020-00645-y

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