A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience

A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience

Environmental temperature changes can alter cell membrane lipid composition but the mechanisms underlying this conserved mechanism are unclear. Here, the authors identify the megaprotein LPD-3 in C. elegans as critical for normal phospholipid distribution and cold resilience.

Bibliographic Details
Main Authors: Changnan Wang, Bingying Wang, Taruna Pandey, Yong Long, Jianxiu Zhang, Fiona Oh, Jessica Sima, Ruyin Guo, Yun Liu, Chao Zhang, Shaeri Mukherjee, Michael Bassik, Weichun Lin, Huichao Deng, Goncalo Vale, Jeffrey G. McDonald, Kang Shen, Dengke K. Ma
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34450-y

Internet

https://doi.org/10.1038/s41467-022-34450-y

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