Loss of p19Arf promotes fibroblast survival during leucine deprivation

Loss of p19Arf promotes fibroblast survival during leucine deprivation

Fibroblasts are quiescent and tumor suppressive in nature but become activated in wound healing and cancer. The response of fibroblasts to cellular stress has not been extensively investigated, however the p53 tumor suppressor has been shown to be activated in fibroblasts during nutrient deprivation...

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Bibliographic Details
Main Authors: Kerry C. Roby, Allyson Lieberman, Bang-Jin Kim, Nicole Zaragoza Rodríguez, Jessica M. Posimo, Tiffany Tsang, Ioannis I. Verginadis, Ellen Puré, Donita C. Brady, Constantinos Koumenis, Sandra Ryeom
Format: Article
Language:English
Published: The Company of Biologists 2022-02-01
Series:Biology Open
Subjects:
p19arf
fibroblast
leucine deprivation
integrated stress response
autophagy
Online Access:http://bio.biologists.org/content/11/2/bio058728

Internet

http://bio.biologists.org/content/11/2/bio058728

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