Molecular interplay between leptin, insulin-like growth factor-1, and β-amyloid in organotypic slices from rabbit hippocampus

Molecular interplay between leptin, insulin-like growth factor-1, and β-amyloid in organotypic slices from rabbit hippocampus

<p>Abstract</p> <p>Background</p> <p>Evidence shows that the insulin-like growth factor-1 (IGF-1) and leptin reduce β-amyloid (Aβ) production and tau phosphorylation, two major hallmarks of Alzheimer's disease (AD). IGF-1 expression involves the JAK/STAT pathway an...

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Bibliographic Details
Main Authors: Dasari Bhanu, Schommer Jared, Prasanthi Jaya RP, Marwarha Gurdeep, Ghribi Othman
Format: Article
Language:English
Published: BMC 2011-06-01
Series:Molecular Neurodegeneration
Subjects:
Leptin
IGF-1
Aβ42
mTORC1
C-EBPα
STAT5
Organotypic slices
Online Access:http://www.molecularneurodegeneration.com/content/6/1/41

Internet

http://www.molecularneurodegeneration.com/content/6/1/41

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