Using FLIM-FRET to measure conformational changes of transglutaminase type 2 in live cells.

Transglutaminase type 2 (TG2) is a ubiquitously expressed member of the transglutaminase family, capable of mediating a transamidation reaction between a variety of protein substrates. TG2 also has a unique role as a G-protein with GTPase activity. In response to GDP/GTP binding and increases in int...

Full description

Bibliographic Details
Main Authors: Nicholas S Caron, Lise N Munsie, Jeffrey W Keillor, Ray Truant
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3432096?pdf=render