Neuroinflammation Upregulated Neuronal Toll-Like Receptors 2 and 4 to Drive Synucleinopathy in Neurodegeneration

Neuroinflammation Upregulated Neuronal Toll-Like Receptors 2 and 4 to Drive Synucleinopathy in Neurodegeneration

Background: Parkinson’s disease (PD) is characterized by intraneuronal α-synuclein aggregation called Lewy bodies and progressive dopaminergic neurodegeneration. Toll-like receptor (TLR) signaling is a major pathway mediating inflammation. The molecular link on how neuroinflammation upregulates neur...

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Bibliographic Details
Main Authors: Lucia Yi-Ru Chung, Yi-Ting Lin, Chi Liu, Yi-Cheng Tai, Han-Yi Lin, Chin-Hsien Lin, Ching-Chow Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
microglia–neuron coculture
neuroinflammation
Toll-like receptors
autophagic flux
synucleinopathy
neurodegeneration
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.845930/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.845930/full

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