Capsazepine (CPZ) Inhibits TRPC6 Conductance and Is Protective in Adriamycin-Induced Nephropathy and Diabetic Glomerulopathy

Capsazepine (CPZ) Inhibits TRPC6 Conductance and Is Protective in Adriamycin-Induced Nephropathy and Diabetic Glomerulopathy

Reactive oxygen species (ROS), which excessively arise in diabetes and systemic inflammatory diseases, modify cellular lipids and cellular lipid composition leading to altered biophysical properties of cellular membranes. The impact of lipid peroxidation on transmembrane signaling routes is not yet...

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Bibliographic Details
Main Authors: Henning Hagmann, Naghmeh Hassanzadeh Khayyat, Mahsa Matin, Cem Oezel, He Chen, Astrid Schauss, Christoph Schell, Thomas Benzing, Stuart Dryer, Paul T. Brinkkoetter
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cells
Subjects:
glomerular disease
podocyte
proteinuria
oxidative stress
lipid peroxidation
Online Access:https://www.mdpi.com/2073-4409/12/2/271

Internet

https://www.mdpi.com/2073-4409/12/2/271

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