Synthesis, biological evaluation and molecular docking study of novel amide-coupled naphthalene scaffolds as potent inhibitors of bacterial recombinase A

Synthesis, biological evaluation and molecular docking study of novel amide-coupled naphthalene scaffolds as potent inhibitors of bacterial recombinase A

The development of antimicrobials having a unique mode of action is essential to solve multi-drug resistance challenges. Herein, we have designed and synthesized novel amide-coupled naphthalene scaffolds (4a-l) by acid-amine coupling reaction of 2-(naphthalen-1-yloxy)acetic acid with various amines....

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Bibliographic Details
Main Authors: Ravi Kalariya, Vikrant Pandya, Nisarg Gohil, Gargi Bhattacharjee, Vijai Singh, Dhanaji P. Rajani, Rajesh Bhosale, Jhillu Singh Yadav
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:European Journal of Medicinal Chemistry Reports
Subjects:
Naphthalene scaffolds
Antimicrobial
RecA inhibitors
Multi-drug resistance
Molecular docking
Online Access:http://www.sciencedirect.com/science/article/pii/S2772417422000504

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http://www.sciencedirect.com/science/article/pii/S2772417422000504

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