Inhibiting NR5A2 targets stemness in pancreatic cancer by disrupting SOX2/MYC signaling and restoring chemosensitivity

Inhibiting NR5A2 targets stemness in pancreatic cancer by disrupting SOX2/MYC signaling and restoring chemosensitivity

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a profoundly aggressive and fatal cancer. One of the key factors defining its aggressiveness and resilience against chemotherapy is the existence of cancer stem cells (CSCs). The important task of discovering upstream regulators of stemn...

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Bibliographic Details
Main Authors: Quan Zheng, Jiajia Tang, Alexandra Aicher, Tony Bou Kheir, Berina Sabanovic, Preeta Ananthanarayanan, Chiara Reina, Minchun Chen, Jian-Min Gu, Bin He, Sonia Alcala, Diana Behrens, Rita T. Lawlo, Aldo Scarpa, Manuel Hidalgo, Bruno Sainz, Patricia Sancho, Christopher Heeschen
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Pancreatic ductal adenocarcinoma
Cancer stem cells
Metabolism
SOX2
MYC
Online Access:https://doi.org/10.1186/s13046-023-02883-y

Internet

https://doi.org/10.1186/s13046-023-02883-y

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