Engineered P450 biocatalysts show improved activity and regio-promiscuity in aromatic nitration

Abstract Nitroaromatics are among the most important and commonly used chemicals but their production often suffers from multiple unsolved challenges. We have previously described the development of biocatalytic nitration processes driven by an engineered P450 TxtE fusion construct. Herein we report...

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Bibliographic Details
Main Authors: Ran Zuo, Yi Zhang, Chao Jiang, John C. Hackett, Rosemary Loria, Steven D. Bruner, Yousong Ding
Format: Article
Language:English
Published: Nature Portfolio 2017-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-00897-z