Inhibitors of Endocannabinoids’ Enzymatic Degradation as a Potential Target of the Memory Disturbances in an Acute N-Methyl-D-Aspartate (NMDA) Receptor Hypofunction Model of Schizophrenia in Mice

Inhibitors of Endocannabinoids’ Enzymatic Degradation as a Potential Target of the Memory Disturbances in an Acute N-Methyl-D-Aspartate (NMDA) Receptor Hypofunction Model of Schizophrenia in Mice

Treating schizophrenia with the available pharmacotherapy is difficult. One possible strategy is focused on the modulation of the function of the endocannabinoid system (ECS). The ECS is comprised of cannabinoid (CB) receptors, endocannabinoids and enzymes responsible for the metabolism of endocanna...

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Bibliographic Details
Main Authors: Marta Kruk-Slomka, Bartlomiej Adamski, Tomasz Slomka, Grazyna Biala
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
endocannabinoids
schizophrenia-like cognitive disorders
FAAH and MAGL inhibitor
NMDA receptor hypofunction
passive avoidance test
mice
Online Access:https://www.mdpi.com/1422-0067/24/14/11400

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https://www.mdpi.com/1422-0067/24/14/11400

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