Identification of small‐molecule elastase inhibitors as antagonists of IL‐36 cytokine activation

Identification of small‐molecule elastase inhibitors as antagonists of IL‐36 cytokine activation

IL‐1 family cytokines act as apical initiators of inflammation in many settings and can promote the production of a battery of inflammatory cytokines, chemokines and other inflammatory mediators in diverse cell types. IL‐36α, IL‐36β and IL‐36γ, which belong to the extended IL‐1 family, have been imp...

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Bibliographic Details
Main Authors: Graeme P. Sullivan, Pavel B. Davidovich, Sylvia Sura‐Trueba, Ekaterina Belotcerkovskaya, Conor M. Henry, Danielle M. Clancy, Anna Zinoveva, Tazhir Mametnabiev, Alexander V. Garabadzhiu, Seamus J. Martin
Format: Article
Language:English
Published: Wiley 2018-05-01
Series:FEBS Open Bio
Subjects:
elastase
IL‐1 family
IL‐36
inflammation
protease
psoriasis
Online Access:https://doi.org/10.1002/2211-5463.12406

Internet

https://doi.org/10.1002/2211-5463.12406

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