Piperazine- and Piperidine-Containing Thiazolo[5,4-<i>d</i>]pyrimidine Derivatives as New Potent and Selective Adenosine A<sub>2A</sub> Receptor Inverse Agonists

Piperazine- and Piperidine-Containing Thiazolo[5,4-<i>d</i>]pyrimidine Derivatives as New Potent and Selective Adenosine A<sub>2A</sub> Receptor Inverse Agonists

The therapeutic use of A<sub>2A</sub> adenosine receptor (AR) antagonists for the treatment of neurodegenerative disorders, such as Parkinson and Alzheimer diseases, is a very promising approach. Moreover, the potential therapeutic role of A<sub>2A</sub> AR antagonists to avo...

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Bibliographic Details
Main Authors: Flavia Varano, Daniela Catarzi, Erica Vigiani, Fabrizio Vincenzi, Silvia Pasquini, Katia Varani, Vittoria Colotta
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Pharmaceuticals
Subjects:
G protein-coupled receptors
adenosine receptors
adenosine A<sub>2A</sub> receptor ligands
thiazolo[5,4-<i>d</i>]pyrimidines
Online Access:https://www.mdpi.com/1424-8247/13/8/161

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https://www.mdpi.com/1424-8247/13/8/161

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