Loss of SETD2 aggravates colorectal cancer progression caused by SMAD4 deletion through the RAS/ERK signalling pathway

Loss of SETD2 aggravates colorectal cancer progression caused by SMAD4 deletion through the RAS/ERK signalling pathway

Abstract Backgound Colorectal cancer (CRC) is a complex, multistep disease that arises from the interplay genetic mutations and epigenetic alterations. The histone H3K36 trimethyltransferase SET domain‐containing 2 (SETD2), as an epigenetic signalling molecule, has a 5% mutation rate in CRC. SETD2 e...

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Bibliographic Details
Main Authors: Chunxiao Ma, Min Liu, Wenxin Feng, Hanyu Rao, Wei Zhang, Changwei Liu, Yue Xu, Ziyi Wang, Yan Teng, Xiao Yang, Li Ni, Jin Xu, Wei‐Qiang Gao, Bing Lu, Li Li
Format: Article
Language:English
Published: Wiley 2023-11-01
Series:Clinical and Translational Medicine
Subjects:
CRC
DUSP7
RAS/ERK signalling pathway
SETD2
SMAD4
Online Access:https://doi.org/10.1002/ctm2.1475

Internet

https://doi.org/10.1002/ctm2.1475

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