Elaiophylin Is a Potent Hsp90/ Cdc37 Protein Interface Inhibitor with K-Ras Nanocluster Selectivity

The natural product elaiophylin is a macrodiolide with a broad range of biological activities. However, no direct target of elaiophylin in eukaryotes has been described so far, which hinders a systematic explanation of its astonishing activity range. We recently showed that the related conglobatin A...

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Bibliographic Details
Main Authors: Farid A. Siddiqui, Vladimir Vukic, Tiina A. Salminen, Daniel Abankwa
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Biomolecules
Subjects:
Online Access:https://www.mdpi.com/2218-273X/11/6/836