Evidence of Adult Features and Functions of Hepatocytes Differentiated from Human Induced Pluripotent Stem Cells and Self-Organized as Organoids

Evidence of Adult Features and Functions of Hepatocytes Differentiated from Human Induced Pluripotent Stem Cells and Self-Organized as Organoids

Background: Human-induced pluripotent stem cell-derived hepatocytes (iHeps) have been shown to have considerable potential in liver diseases, toxicity, and pharmacological studies. However, there is a growing need to obtain iHeps that are truly similar to primary adult hepatocytes in terms of morpho...

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Bibliographic Details
Main Authors: Antonietta Messina, Eléanor Luce, Nassima Benzoubir, Mattia Pasqua, Ulysse Pereira, Lydie Humbert, Thibaut Eguether, Dominique Rainteau, Jean-Charles Duclos-Vallée, Cécile Legallais, Anne Dubart-Kupperschmitt
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cells
Subjects:
liver organoids
hiPSCs
hiPSC-derived hepatocytes
HLCs
self-assembling
hepatic mature functions
Online Access:https://www.mdpi.com/2073-4409/11/3/537

Internet

https://www.mdpi.com/2073-4409/11/3/537

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