Biokinetic parameters of markers of toxicity of methotrexate high dozes
Methotrexate is one of the most effective and widely used cytostatic drugs. However as all antineoplastic drugs it has very low therapeutic index and high toxicity. Kinetic parameters (rate constants, half-times of restoration and extreme values of concentrations at the beginning of methotrexate inf...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Peoples’ Friendship University of Russia (RUDN University)
2008-09-01
|
| Series: | RUDN Journal of Medicine |
| Online Access: | http://journals.rudn.ru/medicine/article/view/3647 |