Interruption of the long non-coding RNA HOTAIR signaling axis ameliorates chemotherapy-induced cachexia in bladder cancer

Interruption of the long non-coding RNA HOTAIR signaling axis ameliorates chemotherapy-induced cachexia in bladder cancer

Abstract Background Cisplatin-based chemotherapy is the first line of treatment for bladder cancer. However, cisplatin induces muscle wasting associated with NF-κB and cancer cachexia. HOTAIR, an oncogenic long non-coding RNA (lncRNA), promotes cancer progression in different cancers. Crosstalk betw...

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Bibliographic Details
Main Authors: Che-Yuan Hu, Bing-Hua Su, Ya-Che Lee, Chung-Teng Wang, Mei-Lin Yang, Wan-Ting Shen, Jing-Ting Fu, Shih-Yao Chen, Wei-Yun Huang, Chien-Hui Ou, Yuh-Shyan Tsai, Feng-Chih Kuo, Ai-Li Shiau, Gia-Shing Shieh, Chao-Liang Wu
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Biomedical Science
Subjects:
HOTAIR
Cachexia
Cisplatin
Bladder cancer
Prothymosin α
EGFR
Online Access:https://doi.org/10.1186/s12929-022-00887-y

Internet

https://doi.org/10.1186/s12929-022-00887-y

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