Genome‐Wide CRISPR/Cas9 Library Screening Revealed Dietary Restriction of Glutamine in Combination with Inhibition of Pyruvate Metabolism as Effective Liver Cancer Treatment

Genome‐Wide CRISPR/Cas9 Library Screening Revealed Dietary Restriction of Glutamine in Combination with Inhibition of Pyruvate Metabolism as Effective Liver Cancer Treatment

Abstract Hepatocellular carcinoma (HCC) is the second most lethal cancer worldwide. Glutamine is an essential, extracellular nutrient which supports HCC growth. Dietary glutamine deficiency may be a potential therapeutic approach for HCC. HCC cells overcome metabolic challenges by rewiring their met...

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Bibliographic Details
Main Authors: Chunxue Yang, Derek Lee, Misty Shuo Zhang, Aki Pui‐Wah Tse, Lai Wei, Macus Hao‐Ran Bao, Bowie Po‐Yee Wong, Cerise Yuen‐Ki Chan, Vincent Wai‐Hin Yuen, Yiling Chen, Carmen Chak‐Lui Wong
Format: Article
Language:English
Published: Wiley 2022-12-01
Series:Advanced Science
Subjects:
CRISPR/Cas9 library screening
dietary intervention
glutamine depletion
hepatocellular carcinoma
pyruvate metabolism
Online Access:https://doi.org/10.1002/advs.202202104

Internet

https://doi.org/10.1002/advs.202202104

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