Pre-Clinical Proof of Concept: Intra-Carotid Injection of Autologous CD34-Positive Cells for Chronic Ischemic Stroke

Pre-Clinical Proof of Concept: Intra-Carotid Injection of Autologous CD34-Positive Cells for Chronic Ischemic Stroke

This study was conducted to evaluate the safety and efficacy of human peripheral blood CD34 positive (CD34+) cells transplanted into a murine chronic stroke model to obtain pre-clinical proof of concept, prior to clinical testing. Granulocyte colony stimulating factor (G-CSF) mobilized human CD34+ c...

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Bibliographic Details
Main Authors: Yuko Ogawa, Yuka Okinaka, Akie Kikuchi-Taura, Orie Saino, Ayumi Tani-Yokoyama, Satoru Masuda, Miki Komatsu-Horii, Yoshihiko Ikemoto, Atsuhiko Kawamoto, Masanori Fukushima, Akihiko Taguchi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Medicine
Subjects:
chronic stroke
peripheral blood CD34 positive cells
hematopoietic stem cells
internal carotid artery
pre-clinical proof of concept
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.681316/full

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https://www.frontiersin.org/articles/10.3389/fmed.2022.681316/full

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